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Thesis

Computational studies of signalling at the cell membrane

Abstract:

In order to associate with the cytoplasmic leaflet of the plasma membrane, many cytosolic signalling proteins possess a distinct lipid binding domain as part of their overall fold. Here, a multiscale simulation approach has been used to investigate three membrane-binding proteins involved in cellular processes such as growth and proliferation. The pleckstrin homology (PH) domain from the general receptor for phosphoinositides 1 (GRP1-PH) binds phosphatidylinositol (3,4,5)-trisphosphate (PI(3,...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Structural Bioinformatics and Computational Biochemistry Unit
Oxford college:
Merton College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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