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Oxidative stress-induced dysregulation of arteriolar wall shear stress and blood pressure in hyperhomocysteinemia is prevented by chronic vitamin C treatment.

Abstract:

We aimed to test the hypothesis that an enhanced level of reactive oxygen species (ROS) is primarily responsible for the impairment of nitric oxide (NO)-mediated regulation of arteriolar wall shear stress (WSS) in hyperhomocysteinemia (HHcy). Thus flow/WSS-induced dilations of pressurized gracilis muscle arterioles (basal diameter: approximately 170 microm) isolated from control (serum Hcy: 6 +/- 1 microM), methionine diet-induced HHcy rats (4 wk, serum Hcy: 30 +/- 6 microM), and HHcy rats tr...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00448.2003

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
285
Issue:
6
Pages:
H2277-H2283
Publication date:
2003-12-01
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Source identifiers:
164438

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