Thesis
Germline determinants of 5-fluorouracil drug toxicity and patient survival in colorectal cancer
- Abstract:
-
Despite a decade of publications investigating the effect of germline polymorphisms on both toxicity related to treatment with 5-fluorouracil-based (5-FU) chemotherapy and prognosis following diagnosis with colorectal cancer (CRC), few genetic biomarkers have been identified convincingly. For 5-FU toxicity and CRC prognosis, in four results chapters, this thesis aims to validate previously-reported genetic biomarkers, identify new markers, determine the mechanistic basis of associated poly...
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Authors
Contributors
+ Ian Tomlinson
Role:
Supervisor
+ Elaine Johnstone
Role:
Supervisor
+ Rachel Midgley
Role:
Supervisor
+ Daniel Norris Rosmarin
Institution:
University of Oxford
Research group:
Molecular and Population Genetics (MPG) Group
Oxford college:
Balliol College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:d5e2c306-689c-4c53-b4c3-2c1001b04ec6
- Local pid:
- ora:8749
Item Description
- Language:
- English
- Keywords:
- Subjects:
Terms of use
- Copyright holder:
- Daniel Rosmarin
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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