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Caveolae in rabbit ventricular myocytes: distribution and dynamic diminution after cell isolation

Abstract:
Introduction: Caveolae are signal transduction centres, yet their subcellular distribution and preservation in cardiac myocytes after cell-isolation are not well documented. Here, we quantify caveolae, located within 100 nm of the outer cell surface membrane, in rabbit single ventricular cardiomyocytes over 8h post-isolation and relate this to caveolae presence in intact tissue. Methods: Hearts from New Zealand white rabbits were either chemically fixed by c... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2017.07.026

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Funding agency for:
Burton, RB
Grant:
Sir Henry Dale Fellowship (109371/Z/15/Z
More from this funder
Funding agency for:
Burton, RB
Grant:
Sir Henry Dale Fellowship (109371/Z/15/Z
Publisher:
Biophysical Society Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
113
Issue:
5
Pages:
1047-1059
Publication date:
2017-09-05
Acceptance date:
2017-07-06
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
710069
Keywords:
Pubs id:
pubs:710069
UUID:
uuid:d656ef0e-9118-42ab-8963-bc12a8b0fd58
Local pid:
pubs:710069
Deposit date:
2017-08-01

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