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Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations

Abstract:

Asthma exacerbations are frightening for patients and are occasionally fatal. We tested the concept that a plan for patients to manage their asthma (self-management plan), which included a temporary quadrupling of the dose of inhaled glucocorticoids when asthma control started to deteriorate, would reduce the incidence of severe asthma exacerbations among adults and adolescents with asthma.We conducted a pragmatic, unblinded, randomized trial involving adults and adolescents with asthma who w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1056/nejmoa1714257

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Grant:
Health Technology Assessment Programme
Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
378
Issue:
10
Pages:
902-910
Publication date:
2018-03-08
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Pmid:
29504499
Language:
English
Pubs id:
pubs:828310
UUID:
uuid:d661df12-1779-400a-9741-e114d7baf301
Local pid:
pubs:828310
Source identifiers:
828310
Deposit date:
2018-04-04

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