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Thesis

Pathogenic mycobacteria achieve cellular persistence via lipid-mediated inhibition of the Niemann-Pick disease type C pathway

Abstract:

M.tuberculosis, the causative agent of human tuberculosis, is able to achieve long-term persistence within host organism macrophages. This persistence is achieved via the ability of the mycobacterium to prevent phagosomal-lysosomal fusion. The mechanisms by which fusion is inhibited remain incompletely understood. Here we provide evidence supporting a mechanistic link between infection with pathogenic mycobacteria and the cellular pathway defective in the rare lysosomal storage di...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Platt Lab
Oxford college:
Merton College
Role:
Author
More by this author
Division:
MSD
Department:
Pharmacology
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:d72cec30-ac7a-43e4-85d7-3450cb184375
Local pid:
ora:9729
Deposit date:
2015-01-13

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