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Pharmacological targeting of the HIF hydroxylases - A new field in medicine development.

Abstract:

In human cells oxygen levels are 'sensed' by a set of ferrous iron and 2-oxoglutarate dependent dioxygenases. These enzymes regulate a broad range of cellular and systemic responses to hypoxia by catalysing the post-translational hydroxylation of specific residues in the alpha subunits of hypoxia inducible factor (HIF) transcriptional complexes. The HIF hydroxylases are now the subject of pharmaceutical targeting by small molecule inhibitors that aim to activate or augment the endogenous HIF ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.mam.2016.01.001

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Strategic
Role:
Author
More from this funder
Grant:
091857/Z/10/Z
106241/Z/14/Z
More from this funder
Grant:
C45605/A16016, C8717/A18245
Ludwig Institute for Cancer Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Molecular Aspects of Medicine Journal website
Volume:
47-48
Pages:
54-75
Publication date:
2016-01-11
Acceptance date:
2016-01-04
DOI:
EISSN:
1872-9452
ISSN:
0098-2997
Source identifiers:
597964
Language:
English
Keywords:
Pubs id:
pubs:597964
UUID:
uuid:d7d1a752-965b-48b1-8a90-2290194a8ee6
Local pid:
pubs:597964
Deposit date:
2016-03-22

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