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Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade

Abstract:

In rheumatoid arthritis (RA), destruction of articular cartilage by the inflamed synovium is considered to be driven by increased activities of proteolytic enzymes, including matrix metalloproteinases (MMPs). The purpose of this study was to investigate the therapeutic potential of selective inhibition of membrane type 1 MMP (MT1-MMP) and its combination with tumor necrosis factor (TNF) blockage in mice with collagen-induced arthritis (CIA).CIA was induced in DBA/1 mice by immunization with b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/art.39414

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
KIR
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Arthritis and Rheumatology Journal website
Volume:
68
Issue:
2
Pages:
521-531
Publication date:
2015-08-28
Acceptance date:
2015-08-20
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
Pmid:
26315469
Source identifiers:
541828

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