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LanCLs have C-glutathionylation activity with potential to trap the eliminylome

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Institution:
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
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Institution:
University of Oxford, UK Catalysis Hub, Research Complex at Harwell, Harwell, Oxford, United Kingdom
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
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Author
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Institution:
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Author
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Institution:
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Sub department:
Chemistry Research Laboratory
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Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Depositor
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Programme:
Science 2: Catalysis at the Water-Energy Nexus
Funding agency for:
Zeng, Y
Grant:
515587 DI DI STF RESEARCHER FF
Publisher:
University of Oxford
Publication date:
2020
DOI:
Language:
English
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Subjects:
Documentation:
Enzyme-mediated damage repair or containment, whilst common for nucleic acids, is rare for proteins. Examples of protein damage are elimination of phosphorylated Ser/Thr to dehydroalanine/dehydrobutyrine (Dha/Dhb) in pathogenic and aging processes. Bacterial LanC enzymes use Dha/Dhb to form intramolecular C–S linkages, but the functions of their LanC-like (LanCL) counterparts in eukarya are unknown. We show that LanCLs catalyze intermolecular addition of glutathione (GSH) to Dha/Dhb in protei... Expand documentation
Deposit date:
2020-12-22

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