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LanCLs have C-glutathionylation activity with potential to trap the eliminylome
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Authors
Contributors
+ Xue, X
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Depositor
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Programme:
Science 2: Catalysis at the Water-Energy Nexus
Funding agency for:
Zeng, Y
Grant:
515587 DI DI STF RESEARCHER FF
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2020
- DOI:
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Documentation:
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Enzyme-mediated damage repair or containment, whilst common for nucleic acids, is rare for proteins. Examples of protein damage are elimination of phosphorylated Ser/Thr to dehydroalanine/dehydrobutyrine (Dha/Dhb) in pathogenic and aging processes. Bacterial LanC enzymes use Dha/Dhb to form intramolecular C–S linkages, but the functions of their LanC-like (LanCL) counterparts in eukarya are unknown. We show that LanCLs catalyze intermolecular addition of glutathione (GSH) to Dha/Dhb in protei... Expand documentation
- Deposit date:
- 2020-12-22
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- Copyright date:
- 2020
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