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Thesis

On genetic variants underlying common disease

Abstract:

Genome-wide association studies (GWAS) exploit the correlation in ge- netic diversity along chromosomes in order to detect effects on disease risk without having to type causal loci directly. The inevitable downside of this approach is that, when the correlation between the marker and the causal variant is imperfect, the risk associated with carrying the predisposing allele is diluted and its effect is underestimated. This thesis explores four different facets of this risk dilution: (1) es...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Donnelly Group
Oxford college:
St John's College
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
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Funding agency for:
Hechter, E
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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