Journal article icon

Journal article

Adenoviral transfer of a single donor-specific MHC class I gene to recipient bone marrow cells can induce specific immunological unresponsiveness in vivo

Abstract:

We investigated the delivery of a donor-specific MHC class I gene, H-2Kb, using a newly constructed replication-defective recombinant adenovirus (AdSV40Kb) to recipient tissue before transplantation as a means of inducing donor-specific immunological unresponsiveness. AdSV40Kb was able to transduce both a fibroblast cell line and freshly isolated bone marrow cells (BMCs) resulting in cell surface expression of H2-Kb protein. Intravenous infusion of AdSV40Kb-transduced syngeneic CBA/Ca (H-2k) ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj/gt/3301648

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
GENE THERAPY
Volume:
9
Issue:
3
Pages:
220-226
Publication date:
2002-02-01
DOI:
ISSN:
0969-7128
Source identifiers:
136033
Language:
English
Keywords:
Pubs id:
pubs:136033
UUID:
uuid:d8b87dde-81b5-44a2-b452-3da804aa44df
Local pid:
pubs:136033
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP