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Methylthioadenosine suppresses Salmonella virulence

Abstract:

In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously we showed transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) in serum during systemic Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Here we explored the functional consequences of increased MTA concentrations on S. Typhimurium virulence. We found that MTA—but not other related metabolite...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/IAI.00429-18

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
St Anne's College
Role:
Author
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Funding agency for:
Bourgeois, J
Grant:
R01AI118903
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Funding agency for:
Thurston, T
Grant:
RSRO_P50016
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Funding agency for:
Gilchrist, J
Grant:
102342/Z/13/Z
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Funding agency for:
Ko, D
Grant:
R01AI118903
Publisher:
American Society for Microbiology Publisher's website
Journal:
Infection and Immunity Journal website
Volume:
86
Issue:
9
Article number:
e00429-18
Publication date:
2018-06-04
Acceptance date:
2018-05-31
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
Pubs id:
pubs:857075
UUID:
uuid:d8cc7fb0-426f-4b96-8c16-a6b91c906cdf
Local pid:
pubs:857075
Deposit date:
2018-06-13

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