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Thesis

The importance of DNA replication termination and the MHF complex to genome stability

Abstract:

The final stages of replication fork termination requires the timely and orderly orchestration of catalytic and enzymatic activities. Given the complexity of this process, it is conceivable that the final stages of fork termination is susceptible to problems that could trigger recombination, which could lead to deleterious genomic rearrangements if ectopic homologous sequences are recombined. Using the site-specific RTS1 barrier in fission yeast, I demonstrated that fork terminati...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Jesus College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:d8f726f9-e18e-43e0-b1f7-96c4f9afb064
Local pid:
ora:11535
Deposit date:
2015-06-01

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