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Thesis

Development of sindbis virus as an oncolytic agent

Abstract:

The poor stability of most therapeutic viruses in the human bloodstream is a major obstacle in the field of cancer virotherapy, preventing systemic intravenous delivery to treat tumour metastases. Delivery is typically limited by inactivation of virus particles by blood components and rapid scavenging by hepatic phagocytes. Members of the Alphavirus family are exposed to blood during natural infections; as such, we hypothesised that evolutionary pressure may have led to blood stability and...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Medicinal Virology Group
Oxford college:
University College
Role:
Author
More by this author
Division:
MSD
Department:
Pharmacology
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
More from this funder
Funding agency for:
Kueberuwa, G
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:d9737357-ab86-4baf-92a9-b4a21b615fd7
Local pid:
ora:6808
Deposit date:
2013-04-16

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