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Thesis

Liver specific microRNA control of adenovirus serotype five

Abstract:

MicroRNAs are small non-coding RNA molecules that regulate mRNA translation by binding to complementary sequences usually within the 3’ un-translated region (UTR). By inserting four perfectly complementary binding sites for the hepatic specific microRNA mir122 into the 3’ UTR of adenovirus wild type 5 (Ad5 WT) E1A mRNA I show that the acute liver toxicity caused by Ad5 WT in mice can be significantly reduced. This virus, termed Ad5-mir122, is a promising virotherapy candidate and causes no...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Medicinal Virology Group - Professor Leonard Seymour
Oxford college:
New College
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
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Funding agency for:
Cawood, R
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:d97d80b5-6272-4aab-b555-d03d0016eeff
Local pid:
ora:9620
Deposit date:
2014-12-18

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