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Journal article : Review

Breaking the paradigm: early insights from mammalian DNA breakomes

Abstract:

DNA double-strand breaks (DSBs) can result from both exogenous and endogenous sources and are potentially toxic lesions to the human genome. If improperly repaired, DSBs can threaten genome integrity and contribute to premature ageing, neurodegenerative disorders and carcinogenesis. Through decades of work on genome stability, it has become evident that certain regions of the genome are inherently more prone to breakage than others, known as genome instability hotspots. Recent advancements in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/febs.15849

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-0902-2364
Cancer Research UK More from this funder
Publisher:
Federation of European Biochemical Societies Publisher's website
Journal:
FEBS Journal Journal website
Volume:
289
Issue:
9
Pages:
2409-2428
Publication date:
2021-05-01
Acceptance date:
2021-03-29
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
Pmid:
33792193
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1170608
Local pid:
pubs:1170608
Deposit date:
2021-12-09

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