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Thesis

The role of non-coding regions of the alpha-synuclein gene in protein expression and the determination of alternatively spliced alpha-synuclein isoforms in oxidatively stressed cells

Abstract:

Parkinson’s disease (PD) is a neurodegenerative disorder caused by substantial loss of dopaminergic neurons and has been extensively linked to alpha synuclein (α-synuclein). This thesis has investigated the non-coding regions and alternatively spliced isoforms of α-synuclein and an improved cell model of PD in which this might be studied. The results indicate that there are several different 5’ untranslated region isoforms of α-synuclein expressed and that these stimulate significantly dif...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
Wood lab, Oxford Parkinson's Disease Centre
Oxford college:
Brasenose College
Role:
Author
More by this author
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
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Funding agency for:
Williams, S
Publication date:
2013
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:d9f4617e-a52a-4339-bb50-993216599f39
Local pid:
ora:7249
Deposit date:
2013-09-03

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