Thesis
Development of biochemical tools to characterise human H3K27 histone demethylase JmjD3
- Abstract:
-
Covalent modifications of histone tails play essential roles in mediating chromatin structure and epigenetic regulation. JmjD3 is a JumonjiC domain containing histone demethylase, belongs to the KDM6 subfamily, and catalyses the removal of methyl groups on methylated lysine 27 on histone 3 (H3K27), a critical mark to promote polycomb mediated repression and gene silencing. The importance of JmjD3 has been implicated in development, cancer biology and immunology.
In this thesis, I re...
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Authors
Contributors
+ Oppermann, U
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Yue, W
Division:
MSD
Department:
NDM
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:da42028f-fe7c-4b9e-b3af-d103ae8b9668
- Local pid:
- ora:7626
- Deposit date:
- 2013-12-09
Terms of use
- Copyright holder:
- Che, K
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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