Multilocus sequence analysis of the pathogen Neisseria meningitidis

Thesis

Neisseria meningitidis is the bacterium responsible for meningococcal meningitis and septicaemia in humans. Meningococcal disease is primarily a disease of young children, characterized by rapid deterioration from first symptoms to death, with an 11% fatality rate and a global distribution. Patterns of genetic diversity in meningococcal populations provide an account of their evolutionary history and structure, which can be inferred by population genetics modelling. Understanding ...

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Authors: Wilson, D

• Publication date: 2005
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: evolution; pathogen; Neisseria meningitidis; meningitis; genetics
• Subjects: Genetics (life sciences); Evolution,ecology and systematics; Mathematical genetics and bioinformatics (statistics)