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Journal article

Fractalkine promotes human monocyte survival via a reduction in oxidative stress.

Abstract:

OBJECTIVE: The CX3C chemokine fractalkine (CX3CL1) has a critical role in the development of atherogenesis because apolipoprotein-E-deficient mice lacking CX3CL1 or its receptor CX3CR1 develop smaller plaques and polymorphisms in CX3CR1 are associated with altered risk of cardiovascular disease. CX3CR1 is found on numerous cell types involved in atherogenesis but seems to have a key role in monocyte function. We aimed to elucidate the role of CX3CL1 in human monocyte survival and determine th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/atvbaha.114.304717

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
McNeill, E
More from this funder
Funding agency for:
Channon, K
Publisher:
American Heart Association Publisher's website
Journal:
Arteriosclerosis, thrombosis, and vascular biology Journal website
Volume:
34
Issue:
12
Pages:
2554-2562
Publication date:
2014-12-01
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Source identifiers:
488359
Language:
English
Keywords:
Pubs id:
pubs:488359
UUID:
uuid:dac033ce-d24d-4086-9713-f8a204d5bcbf
Local pid:
pubs:488359
Deposit date:
2014-11-15

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