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Journal article

Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection.

Abstract:

BACKGROUND: Rare human immunodeficiency virus type 1 (HIV-1)-infected individuals who maintain control of viremia without therapy show potent CD8+ T-cell-mediated suppression of viral replication in vitro. Whether this is a determinant of the rate of disease progression in viremic individuals is unknown. METHODS: We measured CD8+ T-cell-mediated inhibition of a heterologous HIV-1 isolate in 50 HIV-1-seropositive adults with diverse progression rates. Linear mixed models were used to determine...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jis379

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Journal:
Journal of infectious diseases
Volume:
206
Issue:
4
Pages:
552-561
Publication date:
2012-08-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
328216
Language:
English
Keywords:
Pubs id:
pubs:328216
UUID:
uuid:db2942ff-ae11-49b3-be08-2f78a6c2e365
Local pid:
pubs:328216
Deposit date:
2012-12-19

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