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Journal article

Presentation of viral antigen controlled by a gene in the major histocompatibility complex.

Abstract:

We describe a mutant human cell line (LBL 721.174) that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also has a defect in the assembly and expression of class I MHC molecules, which we show can be restored by exposure of the cells to a peptide epitope. This phenotype suggests a defect in the association ...

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Publication status:
Published

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Publisher copy:
10.1038/345449a0

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
Nature
Volume:
345
Issue:
6274
Pages:
449-452
Publication date:
1990-05-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
35138
Language:
English
Keywords:
Pubs id:
pubs:35138
UUID:
uuid:db3d64b6-0842-4649-b073-2a654abe2126
Local pid:
pubs:35138
Deposit date:
2012-12-19

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