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Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation

Abstract:

Neutrophils are critical and short-lived mediators of innate immunity that require constant replenishment. Their differentiation in the bone marrow requires extensive cytoplasmic and nuclear remodeling, but the processes governing these energy-consuming changes are unknown. While previous studies show that autophagy is required for differentiation of other blood cell lineages, its function during granulopoiesis has remained elusive. Here, we have shown that metabolism and autophagy are develo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.immuni.2017.08.005

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Grant:
Investigator award
Publisher:
Cell Press Publisher's website
Journal:
Immunity Journal website
Volume:
47
Issue:
3
Pages:
466-480
Publication date:
2017-08-01
Acceptance date:
2017-06-06
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Source identifiers:
710264
Keywords:
Pubs id:
pubs:710264
UUID:
uuid:dbb9bc14-1f4a-4ae4-bd08-4fc9f53539dc
Local pid:
pubs:710264
Deposit date:
2017-08-03

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