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Thesis

Mathematical modelling of the host-virus interaction in chronic HTLV-I infection and its impact on our understanding of viral persistence and pathogenesis

Abstract:

Human T-cell lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterised by life-long infection and risk of developing one of two major, clinically independent diseases: adult T-cell leukaemia/lymphoma (ATL), an aggressive blood cancer, and HAM/TSP, a progressive neurological and inflammatory disease. Infected individuals typically mount a large, chronically activated CD8+ cytotoxic T-lymphocyte (CTL) response against HTLV-I-infected cells, but ultimately fail to effe...

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Division:
MPLS
Department:
Mathematical Institute
Department:
Wolfson Centre for Mathematical Biology, University of Oxford
Role:
Author

Contributors

Department:
Wolfson Centre for Mathematical Biology, University of Oxford
Role:
Supervisor
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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