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Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial

Abstract:

Objectives CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid versus placebo] in bipolar depression) was a double‐blind, randomized, placebo‐controlled, parallel group, 2×2 factorial trial that examined the effect of adding lamotrigine and/or folic acid (FA) to quetiapine in bipolar depression. Lamotrigine improved depression, but its effectiveness was reduced by FA. We investigated the baseline predicto...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/bdi.12531

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Big Data Institute
Role:
Author
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More from this funder
Funding agency for:
Tunbridge, E
Grant:
Research Fellowship: UF140705
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Funding agency for:
Attenburrow, M
Grant:
Care
CollaborationforLeadershipinAppliedHealthResearch
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Funding agency for:
Attenburrow, M
Grant:
Care
CollaborationforLeadershipinAppliedHealthResearch
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Funding agency for:
Gardiner, A
Grant:
CollaborationforLeadershipinAppliedHealthResearch
Care
More from this funder
Funding agency for:
Hinds, C
Grant:
CollaborationforLeadershipinAppliedHealthResearch
Care
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Publisher:
John Wiley and Sons, Ltd. Publisher's website
Journal:
Bipolar Disorders Journal website
Volume:
19
Issue:
6
Pages:
477-486
Publication date:
2017-08-20
Acceptance date:
2017-07-06
DOI:
EISSN:
1399-5618
ISSN:
1398-5647
Source identifiers:
703112
Keywords:
Pubs id:
pubs:703112
UUID:
uuid:dcdaf6f2-d1e8-488c-8339-6b5314b34d8a
Local pid:
pubs:703112
Deposit date:
2017-07-06

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