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Journal article

A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients

Abstract:

Background: Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue. Balapiravir is a prodrug of a nucleoside analogue (called R1479) and an inhibitor of hepatitis C virus replication in vivo.
Methods: We conducted in vitro experiments to determine the potency of balapiravir against dengue viruses and then an exploratory, dose-escalating, randomized placebo-controlled trial in adult male...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/infdis/jis470

Authors


089276/Wellcome Trust More from this funder
084368/Z/07/Z/Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
207
Issue:
9
Pages:
1442–1450
Publication date:
2012-07-17
Acceptance date:
2012-03-14
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
22807519
Source identifiers:
342305
Keywords:
Pubs id:
pubs:342305
UUID:
uuid:dd45cf9c-f358-4698-b2e1-55cb33c414ea
Local pid:
pubs:342305
Deposit date:
2017-04-26

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