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Nonlinear speech analysis algorithms mapped to a standard metric achieve clinically useful quantification of average Parkinson's disease symptom severity

Abstract:

The standard reference clinical score quantifying average Parkinson's disease (PD) symptom severity is the Unified Parkinson's Disease Rating Scale (UPDRS). At present, UPDRS is determined by the subjective clinical evaluation of the patient's ability to adequately cope with a range of tasks. In this study, we extend recent findings that UPDRS can be objectively assessed to clinically useful accuracy using simple, self-administered speech tests, without requiring the patient's physical presen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsif.2010.0456

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Research group:
"Systems Analysis, Modelling and Prediction (SAMP) group", "Oxford Centre for Industrial and Applied Mathematics (OCIAM)"
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Research group:
"Systems Analysis, Modelling and Prediction (SAMP) group", "Oxford Centre for Industrial and Applied Mathematics (OCIAM)", "Oxford Centre for Integrative Systems Biology"
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
"Systems Analysis, Modelling and Prediction (SAMP) group", "Oxford Centre for Integrative Systems Biology"
Department:
Smith School of Enterprise and the Environment
Role:
Author
More by this author
Institution:
"University of Colorado, Boulder, CO, USA", "National Center for Voice and Speech, Denver, CO, USA"
Department:
Speech,Language,and Hearing Science
Role:
Author
Publisher:
Royal Society Publishing Publisher's website
Journal:
Interface Journal website
Volume:
8
Issue:
59
Pages:
842-855
Publication date:
2011-06-01
DOI:
EISSN:
1742-5662
Language:
English
Keywords:
Subjects:
UUID:
uuid:ddb10a09-654e-4bfd-9e40-653ffbb2d8d5
Local pid:
ora:5791
Deposit date:
2011-10-20

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