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Journal article

Autoimmunizing mechanisms in thymoma and thymus.

Abstract:

Autoimmunizing mechanisms are very hard to study in humans, so we have focused on vital clues in thymomas and hyperplastic thymuses in myasthenia gravis (MG). According to our multi-step hypothesis: thymic epithelial cells (TEC) present epitopes from the isolated acetylcholine receptor (AChR) subunits they express, and autoimmunize helper T cells; subsequently, these evoke "early antibodies" that then attack rare thymic myoid cells expressing intact AChR; in the resulting germinal centers, au...

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Publication status:
Published

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Publisher copy:
10.1196/annals.1405.021

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Journal:
Annals of the New York Academy of Sciences
Volume:
1132
Pages:
163-173
Publication date:
2008-01-01
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
Source identifiers:
148682
Language:
English
Keywords:
Pubs id:
pubs:148682
UUID:
uuid:ddb39199-6daa-4aef-b143-e6c1ca90bd35
Local pid:
pubs:148682
Deposit date:
2012-12-19

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