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Journal article

Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition

Abstract:

Invariant natural killer T (iNKT) cells recognize self lipid antigens presented by CD1d molecules. The nature of the self-antigens involved in the development and maturation of iNKT cells is poorly defined. Lysophospholipids are self-antigens presented by CD1d that are generated through the action of phospholipases A1 and A2. Lysosomal phospholipase A2 (LPLA2, group XV phospholipase A2) resides in the endocytic system, the main site where CD1d antigen acquisition occurs, suggesting that it co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1302923110

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0003-1441-1727
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Howard Hughes Medical Institute More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Issue:
13
Publication date:
2014-03-14
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
23493550
Source identifiers:
627581
Language:
English
Keywords:
Pubs id:
pubs:627581
UUID:
uuid:de472a1c-fc0c-4746-a155-c90cfeaa904d
Local pid:
pubs:627581
Deposit date:
2018-03-05

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