Journal article
Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction
- Abstract:
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Chemokines mediate leucocyte migration and homeostasis, and are key targets in inflammatory diseases including atherosclerosis, cytokine storm and chronic auto-immune disease. Chemokine redundancy and ensuing network robustness has frustrated therapeutic development. Salivary evasins from ticks bind multiple chemokines overcoming redundancy, and are effective in several pre-clinical disease models. Their clinical development has not progressed due to concerns regarding potential immunogenicit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 3.1MB)
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- Publisher copy:
- 10.1074/jbc.ra120.014103
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 395
- Issue:
- 32
- Pages:
- 10926-10939
- Publication date:
- 2020-05-29
- Acceptance date:
- 2020-05-29
- DOI:
- EISSN:
-
1083-351X
- ISSN:
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0021-9258
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1107652
- Local pid:
- pubs:1107652
- Deposit date:
- 2020-05-30
Terms of use
- Copyright holder:
- The American Society for Biochemistry and Molecular Biology, Inc.
- Copyright date:
- 2020
- Rights statement:
- Published under license by The American Society for Biochemistry and Molecular Biology, Inc. This is an Open Access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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