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Journal article

N-glycan microheterogeneity regulates interactions of plasma proteins

Abstract:

Altered glycosylation patterns of plasma proteins are associated with autoimmune disorders and pathogenesis of various cancers. Elucidating glycoprotein microheterogeneity and relating subtle changes in the glycan structural repertoire to changes in protein–protein, or protein–small molecule interactions, remains a significant challenge in glycobiology. Here, we apply mass spectrometry-based approaches to elucidate the global and site-specific microheterogeneity of two plasma proteins: α1-aci...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1073/pnas.1807439115

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0001-7829-5505
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Grant:
Investigator Award 104633/Z/14/Z
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Grant:
Advanced Grant ENABLE (641317
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
35
Pages:
8763-8768
Publication date:
2018-08-15
Acceptance date:
2018-07-13
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
30111543
Source identifiers:
909867
Language:
English
Keywords:
Pubs id:
pubs:909867
UUID:
uuid:df879ce2-8377-4a03-945f-47620e528ac8
Local pid:
pubs:909867
Deposit date:
2018-08-30

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