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Thesis

Investigating the biology of nuclear IGF-1R in prostate cancer

Abstract:

Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase comprised of two extracellular α- and two transmembrane β-subunits in a heterotetrameric structure. IGF-axis signalling is implicated in cancer progression, metastasis and resistance to treatment including radiotherapy. Recent work by our lab and others has shown the presence and activity of IGF-1R in the nucleus of a range of cancer cell types, interacting with nuclear proteins and undergoing recrui...

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Division:
MSD
Department:
Oncology
Sub department:
Oncology
Research group:
Macaulay Lab
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0002-1852-4596

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Sub department:
Surgical Sciences
Research group:
Macaulay Lab
Role:
Supervisor
ORCID:
0000-0001-8659-0192
Role:
Supervisor
Division:
MSD
Department:
Oncology
Role:
Examiner
Institution:
Karolinska Institute
Role:
Examiner
More from this funder
Programme:
MRC Industrial Strategy Studentship
Funding agency for:
Mills, JV
Grant:
1718_MSD_1113081
More from this funder
Programme:
Cancer Research UK Development Fund
Funding agency for:
Macaulay, V
Mills, JV
Grant:
CRUKDF - 0221 – VMIMJM
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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