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Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding

Abstract:

Using a cytological assay to monitor the successive chromatin association of replication proteins leading to replication initiation, we have investigated the function of fission yeast Cdc23/Mcm10 in DNA replication. Inactivation of Cdc23 before replication initiation using tight degron mutations has no effect on Mcm2 chromatin association, and thus pre-replicative complex (pre-RC) formation, although Cdc45 chromatin binding is blocked. Inactivating Cdc23 during an S phase block after Cdc45 ha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Association for International Cancer Research More from this funder
Cancer Research UK More from this funder
Publisher:
American Society for Cell Biology Publisher's website
Journal:
Molecular Biology of the Cell Journal website
Volume:
14
Issue:
9
Pages:
3876-3887
Publication date:
2003-09-01
ISSN:
1059-1524
Language:
English
Keywords:
Subjects:
UUID:
uuid:dfa370e4-7088-400c-b5e5-52c3be64fb48
Local pid:
ora:1690
Deposit date:
2008-03-14

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