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Journal article

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization.

Abstract:

Although peroxisome proliferator-activated receptor gamma (PPARγ) agonists such as thiazolidinediones (TZDs) are widely used to treat type 2 diabetes, how its activation in individual tissues contributes to TZD's therapeutic action remains controversial. As TZDs are known to have receptor-independent effects, we sought to establish gain-of-function animal models to delineate the receptor's insulin-sensitizing actions. Unexpectedly, we find that selective activation of PPARγ in adipocytes, but...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.0912487106

Authors


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Howard Hughes Medical Institute More from this funder
Helmsley Charitable Trust More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
106
Issue:
52
Pages:
22504-22509
Publication date:
2009-12-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
12716

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