Thesis
Development of small molecule inhibitors of the bromodomain-histone interaction
- Abstract:
-
Bromodomains bind to acetylated lysine residues 1 to mediate a wide range of biological processes, including the assembly of transcriptional machinery at modified histones. This thesis describes the design of small molecule inhibitors of bromodomains, with particular focus on the bromodomain of CREBBP.
A fragment based approach was employed to investigate bicyclic amides as acetyl lysine mimics. Initially the benzoxazinone scaffold (BNZ) 2 was shown to be a novel, ligand efficient b...
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Authors
Contributors
+ Conway, S
Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
+ Brennan, P
Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:dfe22076-befc-4881-8433-b563a9329478
- Local pid:
- ora:12217
- Deposit date:
- 2015-09-07
Terms of use
- Copyright holder:
- Timothy P C Rooney
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available via ORA.
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