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Structural explanation for the role of Mn^2+ in the activity of Φ6 RNA-dependent RNA polymerase

Abstract:

The biological role of manganese (MN^2+) has been a long-standing puzzle, since at low concentrations it activates several polymerases whilst at higher concentrations it inhibits. Viral RNA polymerases possess a common architecture, reminiscent of a closed right hand. The RNA-dependent RNA polymerase (RdRp) of bacteriophage Φ6 is one of the best understood examples of this important class of polymerases. We have probed the role of MN^2+ by biochemical, biophysical and structural analyses of t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkn632

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Institution:
University of Helsinki
Department:
Department of Biological and Environmental Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Helsinki
Department:
Department of Biological and Environmental Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Helsinki
Department:
Department of Biological and Environmental Sciences
Role:
Author
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Funding agency for:
Bamford, D
Grant:
"!213992", "1213467"
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Funding agency for:
Grimes, J
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
36
Issue:
20
Pages:
6633-6644
Publication date:
2008-11-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Subjects:
UUID:
uuid:dff24792-571a-48c2-85aa-9af765ff6051
Local pid:
ora:2808
Deposit date:
2009-06-04

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