Thesis icon

Thesis

Haploid genetic screening approach towards identifying novel regulators of immune checkpoints

Abstract:

Priming the immune system by blockade of immune checkpoint proteins has revolutionized cancer therapy and achieved durable clinical responses. Despite the success of targeting the PD1-PDL1 axis or CTLA-4 to release the breaks on T cells, the response across cancer types and patients has not been uniform. One of the reasons is the heterogenous immune evasion mechanisms displayed by the tumour. With over forty immune checkpoint proteins identified, there remains much to understand regarding ...

Expand abstract

Actions


Authors


More by this author
Division:
MSD
Department:
NDM
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
More from this funder
Programme:
CRUK Oxford centre DPhil prize studentship
Grant:
CRUK-OC-DPhil17-VC
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Deposit date:
2022-05-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP