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Thesis

Computational strategies to overcome antibiotic resistance: Exploring novel tetramic acids as Undecaprenyl Pyrophosphate Synthase (UPPS) inhibitors

Abstract:

The rise of multiple antibiotic resistance is a critical obstacle to the design and development of novel antimicrobial agents. The historical paradigm of monotherapies (i.e., drugs acting on single biological targets) has been replaced in recent years by multi-targeting therapies (e.g., antibiotic combinations and hybrids) which act on two or more targets. The efficacy of this multi-targeting approach is increased if the targets belong to divergent metabolic pathways, thereby minimising th...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
MGM
Oxford college:
University College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
MGM
Oxford college:
St Peter's College
Role:
Supervisor
ORCID:
0000-0002-4440-3632
More from this funder
Programme:
Synthesis for Biology and Medicine (SBM) Centre for Doctoral Training (CDT)
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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