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Large-scale candidate gene analysis of HDL particle features.

Abstract:

BACKGROUND: HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism. We therefore assessed HDL particles by NMR spectroscopy and conducted a large-scale candidate gene association analysis. METHODOLOGY/PRINCIPAL FINDINGS: We measured plasma HDL-C and determined mean HDL particle size and particle number by NMR spec...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0014529

Authors


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Medical Research Council More from this funder
European Union More from this funder
National Genome Network More from this funder
British Heart Foundation More from this funder
Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
1
Article number:
e14529
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
118156
Language:
English
Keywords:
Pubs id:
pubs:118156
UUID:
uuid:e10c9876-bb91-4ba0-933e-cf409288ff2d
Local pid:
pubs:118156
Deposit date:
2012-12-19

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