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Correcting for purifying selection: an improved human mitochondrial molecular clock

Abstract:

There is currently no calibration available for the whole human mtDNA genome, incorporating both coding and control regions. Furthermore, as several authors have pointed out recently, linear molecular clocks that incorporate selectable characters are in any case problematic. We here confirm a modest effect of purifying selection on the mtDNA coding region and propose an improved molecular clock for dating human mtDNA, based on a worldwide phylogeny of > 2000 complete mtDNA genomes and cali...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ajhg.2009.05.001

Authors


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Institution:
University of Leeds
Department:
Institute of Integrative and Comparative Biology,Faculty of Biological Sciences
Role:
Author
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Institution:
"University of Leeds", "Università di Camerino, Italy"
Department:
Laboratorio di Archeo=Antropologia molecolare/DNA antico
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Author
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Institution:
University of Glasgow
Department:
Department of Statistics
Role:
Author
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Institution:
"University of Leeds", "University of Cambridge"
Department:
Leverhulme Centre for Human Evolutionary Studies
Role:
Author
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Institution:
University of Liverpool
Department:
Liverpool School of Tropical Medicine
Role:
Author
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Contributors

European Union More from this funder
Bradshaw Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
84
Issue:
6
Pages:
740-759
Publication date:
2009-01-01
DOI:
ISSN:
0002-9297
Language:
English
Keywords:
Subjects:
UUID:
uuid:e150ce15-bb1a-41a5-8be6-8afaf3420e76
Local pid:
ora:5573
Deposit date:
2011-07-18

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