Functions of the orbital prefrontal cortex and hippocampus in goal-directed behavior and memory

Thesis

Ailments such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are devastating conditions linked to deficits in the human prefrontal cortex, with some apparent localization to the orbital prefrontal cortex (OPFC). Prior work suggests structural and functional homology in the prefrontal cortex across species but many discrepancies remain. The primary aim of this project was thus to characterize the behavioral similarities and differences of the OPFC. Cytotoxic ablations of either...

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Authors: Mariano, T

• Publication date: 2006
• Type of award: MSc
• Level of award: Masters
• Awarding institution: University of Oxford
• Language: English
• Keywords: spatial behavior; memory; hippocampus; goal-directed behavior; orbital frontal cortex; executive function
• Subjects: Cognitive Neuroscience; Experimental psychology; Behavioural Neuroscience; Neuropsychology