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Thesis

Genetic, functional, and phenotypic analysis of human variants in the glucokinase regulatory protein gene

Abstract:

Genome-wide association (GWA) studies have provided significant insight into the underlying genetic components of common human diseases such as type 2 diabetes (T2D). However, the translation of such genetic findings into biological and clinical insight remains a major challenge. One of the genes implicated in T2D pathogenesis and effects on related glycaemic and lipidaemic traits by the GWA approach is GCKR, encoding glucokinase regulatory protein (GKRP). GKRP inhibits the glycolytic enzy...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Research group:
Diabetes Research Laboratory
Oxford college:
Magdalen College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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