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Journal article

Filtering next-generation sequencing of the Ig gene repertoire data using antibody structural information

Abstract:

Next-generation sequencing of the Ig gene repertoire (Ig-seq) produces large volumes of information at the nucleotide sequence level. Such data have improved our understanding of immune systems across numerous species and have already been successfully applied in vaccine development and drug discovery. However, the high-throughput nature of Ig-seq means that it is afflicted by high error rates. This has led to the development of error-correction approaches. Computational error-correction meth...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1800669

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Role:
Author
ORCID:
0000-0003-3806-8302
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0001-7146-9322
More by this author
Role:
Author
ORCID:
0000-0003-4855-7329
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Oxford college:
Kellogg College
Role:
Author
ORCID:
0000-0003-1388-2252
More from this funder
Funding agency for:
Kovaltsuk, A
Grant:
BB/M011224/1
More from this funder
Funding agency for:
Kovaltsuk, A
Grant:
BB/M011224/1
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
201
Issue:
12
Pages:
3694-3704
Publication date:
2018-12-10
Acceptance date:
2018-10-02
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pmid:
30397033
Source identifiers:
942205
Language:
English
Pubs id:
pubs:942205
UUID:
uuid:e1edb605-c0b7-4cce-ab14-6f9e18283661
Local pid:
pubs:942205
Deposit date:
2018-11-28

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