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The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

Abstract:

Background: The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ), with amodiaquine being also widely used as part of seasonal malaria chemoprevention programs combined with sulfadoxine-pyrimethamine. While artemisinin derivatives have a short half-life, lumefantrine and amodiaquine may give rise to differing durations of po...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12916-020-1494-3

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0002-2158-846X
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Role:
Author
ORCID:
0000-0002-1713-6209
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Medical Research Council More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medicine Journal website
Volume:
18
Issue:
1
Article number:
47
Publication date:
2020-02-25
Acceptance date:
2020-01-09
DOI:
EISSN:
1741-7015
Pmid:
32098634

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