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Thesis

Screening for inhibitors of and novel proteins within the homologous recombination DNA repair pathway

Abstract:

The homologous recombination (HR) pathway of DNA repair is essential for the faithful repair of double-stranded DNA breaks (DSBs) in all organisms and as such helps maintain genomic stability. Furthermore, HR is instrumental in the cellular response to exogenous DNA damaging agents such as those used in the clinic for chemo- and radiotherapy. HR in humans is a complex, incompletely understood process involving numerous stages and diverse biochemical activities. Advancing our knowledge of the ...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
Linacre College
Role:
Author

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Role:
Supervisor
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Funding agency for:
Kingham, G
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:e2988d0b-c6d4-42a8-aef9-f320a13d6391
Local pid:
ora:6169
Deposit date:
2012-04-17

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