Thesis
Imaging the assembly of the Staphylococcal pore-forming toxin alpha-Hemolysin
- Abstract:
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Alpha-hemolysin is a pore-forming toxin secreted by pathogenic Staphylococcus aureus. Its spontaneous oligomerization and assembly into a trans-bilayer beta-barrel pore is a model for the assembly of many other pore-forming toxins. It is studied here in vitro as a means to probe general membrane protein oligomerization and lipid bilayer insertion. This thesis details the results of experiments to develop and implement a novel in vitro lipid bilayer system, Droplet-on-Hydrogel Bilayers (DHBs) ...
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Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Thompson, J
Bibliographic Details
- Publication date:
- 2009
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:e320004a-6118-4dac-af2a-eca6e90be7ac
- Local pid:
- ora:2811
- Deposit date:
- 2009-06-04
Terms of use
- Copyright holder:
- James R. Thompson
- Copyright date:
- 2009
- Notes:
- Please note that the full text of chapters 2, 4 and 5 of the thesis cannot be made freely available in ORA for copyright reasons. However, you may be able to access the articles based on these chapters by clicking on the related item links from this ORA record page, or by clicking on the links from the pdf.
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