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Synaptic transmission optimization predicts expression loci of long-term plasticity

Abstract:

Long-term modifications of neuronal connections are critical for reliable memory storage in the brain. However, their locus of expression—pre- or postsynaptic—is highly variable. Here we introduce a theoretical framework in which long-term plasticity performs an optimization of the postsynaptic response statistics toward a given mean with minimal variance. Consequently, the state of the synapse at the time of plasticity induction determines the ratio of pre- and postsynaptic modifications. Ou...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuron.2017.09.021

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Funding agency for:
Costa, R
Grant:
Sir Henry Dale Fellowship (WT 100000
More from this funder
Funding agency for:
Costa, R
Grant:
Sir Henry Dale Fellowship (WT 100000
More from this funder
Funding agency for:
Padamsey, Z
Grant:
BB/5018724/1
Publisher:
Cell Press Publisher's website
Journal:
Neuron Journal website
Volume:
96
Issue:
1
Pages:
177–189.e7
Publication date:
2017-09-27
Acceptance date:
2017-09-13
DOI:
ISSN:
0896-6273
Keywords:
Pubs id:
pubs:730234
UUID:
uuid:e3377739-286f-4a82-8084-b2914b17c704
Local pid:
pubs:730234
Deposit date:
2017-09-22

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