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Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Abstract:

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet, when WASP function is eliminated there is negligible effect on actin polymerization at the immunological synapse, leading to gaps in our understanding of the events connecting WASP and calcium ion signaling. Here, we identify a fraction of t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Funding agency for:
Depoil, D
Grant:
PN2EY016586
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Funding agency for:
Depoil, D
Grant:
Annual Grant
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Funding agency for:
Depoil, D
Grant:
NYUMC microscopy core
Publisher:
eLife Sciences Publisher's website
Journal:
eLIFE
Volume:
2015;4:e04953
DOI:
ISSN:
2050-084X
Language:
English
Keywords:
Subjects:
UUID:
uuid:e33d2744-7519-4abc-a503-5aab7ce29be9
Deposit date:
2015-05-11

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