Journal article
CMV-associated T cell and NK cell terminal differentiation does not impact immunogenicity of ChAdOx1 vaccination
- Abstract:
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Cytomegalovirus (CMV) is a globally ubiquitous pathogen with a seroprevalence of approximately 50% in the United Kingdom. CMV infection induces expansion of immunosenescent T cell and NK cell populations, with these cells demonstrating lower responsiveness to activation and reduced functionality upon infection and vaccination. In this study, we found that CMV+ participants had normal T cell responses after a single-dose or homologous vaccination with the viral vector chimpanzee adenovirus dev...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 3.0MB)
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- Publisher copy:
- 10.1172/jci.insight.154187
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Authors
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI Insight Journal website
- Volume:
- 7
- Issue:
- 6
- Article number:
- e154187
- Place of publication:
- United States
- Publication date:
- 2022-02-22
- Acceptance date:
- 2022-02-02
- DOI:
- EISSN:
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2379-3708
- Pmid:
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35192547
Item Description
Terms of use
- Copyright holder:
- Sharpe et al.
- Copyright date:
- 2022
- Rights statement:
- ©2022, Sharpe et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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