Journal article icon

Journal article

CMV-associated T cell and NK cell terminal differentiation does not impact immunogenicity of ChAdOx1 vaccination

Abstract:

Cytomegalovirus (CMV) is a globally ubiquitous pathogen with a seroprevalence of approximately 50% in the United Kingdom. CMV infection induces expansion of immunosenescent T cell and NK cell populations, with these cells demonstrating lower responsiveness to activation and reduced functionality upon infection and vaccination. In this study, we found that CMV+ participants had normal T cell responses after a single-dose or homologous vaccination with the viral vector chimpanzee adenovirus dev...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1172/jci.insight.154187

Authors


Expand authors...
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
7
Issue:
6
Article number:
e154187
Place of publication:
United States
Publication date:
2022-02-22
Acceptance date:
2022-02-02
DOI:
EISSN:
2379-3708
Pmid:
35192547
Language:
English
Keywords:
Pubs id:
1241158
Local pid:
pubs:1241158
Deposit date:
2022-03-15

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP