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Elimination of latently HIV-infected cells from antiretroviral therapy-suppressed subjects by engineered immune-mobilizing T-cell receptors.

Abstract:

Persistence of human immunodeficiency virus (HIV) in a latent state in long-lived CD4+ T-cells is a major barrier to eradication. Latency-reversing agents that induce direct or immune-mediated cell death upon reactivation of HIV are a possible solution. However, clearance of reactivated cells may require immunotherapeutic agents that are fine-tuned to detect viral antigens when expressed at low levels. We tested the antiviral efficacy of immune-mobilizing monoclonal T-cell receptors against v...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/mt.2016.114

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Molecular Therapy Journal website
Volume:
24
Issue:
11
Pages:
1913-1925
Publication date:
2016-12-01
Acceptance date:
2016-05-24
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Pmid:
27401039
Source identifiers:
633896
Language:
English
Keywords:
Pubs id:
pubs:633896
UUID:
uuid:e4576e39-5224-46e7-947c-70801d24c694
Local pid:
pubs:633896
Deposit date:
2017-12-21

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